53 articles for thisTarget
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Article Title
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Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.
University of Bath
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
Brandeis University
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.
University of Minnesota
Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
Brandeis University
Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.
Chinese Academy of Sciences
Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.
Brandeis University
Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
Brandeis University
Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.
Pharmasset
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
TBA
Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.
Codon Pharmaceuticals
Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.
Universit£
Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.
Codon Pharmaceuticals
Rationally designed inhibitors of inosine monophosphate dehydrogenase.
University of Chicago
The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives.
Shenyang Pharmaceutical University
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.
University of Minnesota
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.
Hokkaido University
Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.
University of Minnesota
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.
University of Minnesota
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
University of Minnesota
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.
University of Minnesota
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.
University of Minnesota
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
Gilead Sciences
Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Ucb Pharma
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Ucb Pharma
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Celltech R and D
3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Bristol-Myers Squibb Pharmaceutical Research Institute
Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Bristol-Myers Squibb Pharmaceutical Research Institute
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Bristol-Myers Squibb Pharmaceutical Research Institute
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Bristol-Myers Squibb Pri
Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
Bristol-Myers Squibb Pri
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Bristol-Myers Squibb Pri
The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.
Bristol-Myers Squibb Pharmaceutical Research Institute
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
Bristol-Myers Squibb Pri
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Novel diamide-based inhibitors of IMPDH.
Bristol-Myers Squibb Pharmaceutical Research Institute
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid.
Syntex Research
Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.
Hokkaido University
Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
The University of Queensland
Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.
National Institute of Allergy and Infectious Diseases
Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.
Nycomed
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis.
Brandeis University
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Bristol-Myers Squibb